Identification, Genetic Analysis, and Pathogenicity of Classical Swine H1N1 and Human-Swine Reassortant H1N1 Influenza Viruses from Pigs in China.
Identifieur interne : 000013 ( Main/Exploration ); précédent : 000012; suivant : 000014Identification, Genetic Analysis, and Pathogenicity of Classical Swine H1N1 and Human-Swine Reassortant H1N1 Influenza Viruses from Pigs in China.
Auteurs : Yafen Song [République populaire de Chine] ; Yong Zhang [République populaire de Chine] ; Bing Zhang [République populaire de Chine] ; Ling Chen [République populaire de Chine] ; Min Zhang [République populaire de Chine] ; Jingwen Wang [République populaire de Chine] ; Ying Jiang [République populaire de Chine] ; Chenghuai Yang [République populaire de Chine] ; Taozhen Jiang [République populaire de Chine]Source :
- Viruses [ 1999-4915 ] ; 2020.
Abstract
Swine influenza virus causes a substantial disease burden to swine populations worldwide and poses an imminent threat to the swine industry and humans. Given its importance, we characterized two swine influenza viruses isolated from Shandong, China. The homology and phylogenetic analyses showed that all eight gene segments of A/swine/Shandong/AV1522/2011(H1N1) were closely related to A/Maryland/12/1991(H1N1) circulating in North America. The HA, NA, M, and NS genes of the isolate were also confirmed to have a high homology to A/swine/Hubei/02/2008(H1N1) which appeared in China in 2008, and the virus was clustered into the classical swine lineage. The gene segments of A/swine/Shandong/AV1523/2011(H1N1) were highly homologous to the early human H1N1 and H2N2 influenza viruses, except for the HA gene, and the virus was a reassortant H1N1 virus containing genes from the classical swine (HA) and human (NA, PB2, PB1, PA, NP, M, and NS) lineages. Both the viruses could cause lethal infection and replicate efficiently in the lungs, brains, spleens, and kidneys of mice. Histopathological examinations showed that AV1522 and AV1523 viruses caused a spectrum of marked pneumonia and meningoencephalitis according to the duration of infection, demonstrating a progression of respiratory disease and neurological disease over the course of infection that ultimately resulted in lethality for the infected mice. The changes in the pathogenicity of swine influenza viruses to mammals, accompanied with the continuous reassortment and evolution of the viruses, highlights the importance of ongoing epidemiological investigation.
DOI: 10.3390/v12010055
PubMed: 31906591
Affiliations:
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Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jiang, Ying" sort="Jiang, Ying" uniqKey="Jiang Y" first="Ying" last="Jiang">Ying Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yang, Chenghuai" sort="Yang, Chenghuai" uniqKey="Yang C" first="Chenghuai" last="Yang">Chenghuai Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jiang, Taozhen" sort="Jiang, Taozhen" uniqKey="Jiang T" first="Taozhen" last="Jiang">Taozhen Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Swine influenza virus causes a substantial disease burden to swine populations worldwide and poses an imminent threat to the swine industry and humans. Given its importance, we characterized two swine influenza viruses isolated from Shandong, China. The homology and phylogenetic analyses showed that all eight gene segments of A/swine/Shandong/AV1522/2011(H1N1) were closely related to A/Maryland/12/1991(H1N1) circulating in North America. The HA, NA, M, and NS genes of the isolate were also confirmed to have a high homology to A/swine/Hubei/02/2008(H1N1) which appeared in China in 2008, and the virus was clustered into the classical swine lineage. The gene segments of A/swine/Shandong/AV1523/2011(H1N1) were highly homologous to the early human H1N1 and H2N2 influenza viruses, except for the HA gene, and the virus was a reassortant H1N1 virus containing genes from the classical swine (HA) and human (NA, PB2, PB1, PA, NP, M, and NS) lineages. Both the viruses could cause lethal infection and replicate efficiently in the lungs, brains, spleens, and kidneys of mice. Histopathological examinations showed that AV1522 and AV1523 viruses caused a spectrum of marked pneumonia and meningoencephalitis according to the duration of infection, demonstrating a progression of respiratory disease and neurological disease over the course of infection that ultimately resulted in lethality for the infected mice. The changes in the pathogenicity of swine influenza viruses to mammals, accompanied with the continuous reassortment and evolution of the viruses, highlights the importance of ongoing epidemiological investigation.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Song, Yafen" sort="Song, Yafen" uniqKey="Song Y" first="Yafen" last="Song">Yafen Song</name></noRegion><name sortKey="Chen, Ling" sort="Chen, Ling" uniqKey="Chen L" first="Ling" last="Chen">Ling Chen</name><name sortKey="Jiang, Taozhen" sort="Jiang, Taozhen" uniqKey="Jiang T" first="Taozhen" last="Jiang">Taozhen Jiang</name><name sortKey="Jiang, Ying" sort="Jiang, Ying" uniqKey="Jiang Y" first="Ying" last="Jiang">Ying Jiang</name><name sortKey="Wang, Jingwen" sort="Wang, Jingwen" uniqKey="Wang J" first="Jingwen" last="Wang">Jingwen Wang</name><name sortKey="Yang, Chenghuai" sort="Yang, Chenghuai" uniqKey="Yang C" first="Chenghuai" last="Yang">Chenghuai Yang</name><name sortKey="Zhang, Bing" sort="Zhang, Bing" uniqKey="Zhang B" first="Bing" last="Zhang">Bing Zhang</name><name sortKey="Zhang, Min" sort="Zhang, Min" uniqKey="Zhang M" first="Min" last="Zhang">Min Zhang</name><name sortKey="Zhang, Yong" sort="Zhang, Yong" uniqKey="Zhang Y" first="Yong" last="Zhang">Yong Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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